OCLC provides access to presentations made through its Distinguished Speakers Series here. The last two speakers have focused on managing unique local collections.
This month Richard Ovenden (Keeper of Special Collections and Associate Director of the Bodleian Library at the University of Oxford) discussed some of his institution's initiatives for managing unique local collections (as opposed to uniform universal collections [the easy but expensive stuff]). See the webcast here.
Last month Tom Hickerson (Vice Provost for Libraries and Cultural Resources and University Librarian at the